Human Platelet-Specific Antigen, Sib", Is Associated With the Molecular Weight Polymorphism
نویسندگان
چکیده
Platelet-specific antigen Sib' has been highly implicated in the pathogenesis of refractoriness to human leukocyte antigen (HLA)-matched platelet transfusions in Japan. We provide evidence that the Sib' antigen is located on the glycoprotein (GP) Iba and has a close association with the molecular weight (mol wt) polymorphism of GPlb. In modified antigencapture ELISA (MACE), anti-Sib' antibody reacted only with GPlb/lX held by a murine anti-GPlb/lX monoclonal antibody (MoAb). The reactivity of anti-Sib' antibody to Sib'-positive (Sib'+) platelets was abolished after they were treated with Serratia marcescens protease. Platelets from 50 healthy volunteers were semiquantitatively phenotyped for Sib' antigen by MACE and divided into three distinct groups: strongly
منابع مشابه
Human platelet-specific antigen, Siba, is associated with the molecular weight polymorphism of glycoprotein Ib alpha.
Platelet-specific antigen Sib(a) has been highly implicated in the pathogenesis of refractoriness to human leukocyte antigen (HLA)-matched platelet transfusions in Japan. We provide evidence that the Sib(a) antigen is located on the glycoprotein (GP) Ib alpha and has a close association with the molecular weight (mol wt) polymorphism of GPIb. In modified antigen-capture ELISA (MACE), anti-Sib(a...
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